Giant Cell Arteritis

A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)

Also Known As:

Horton Disease; Juvenile Temporal Arteritis; Arteritis, Temporal; Cranial Arteritis; Arteritis, Giant Cell, Horton; Arteritis, Giant Cell, Horton's; Giant Cell Aortic Arteritis; Giant Cell Aortitis; Giant Cell Aortitis, Horton's; Giant Cell Arteritis, Horton; Horton's Disease; Horton's Giant Cell Arteritis; Aortitides, Giant Cell; Arteritides, Cranial; Arteritides, Giant Cell; Arteritides, Juvenile Temporal; Arteritides, Temporal; Arteritis, Cranial; Arteritis, Giant Cell; Arteritis, Juvenile Temporal; Cranial Arteritides; Giant Cell Aortitides; Giant Cell Arteritides; Hortons Disease; Juvenile Temporal Arteritides; Temporal Arteritides; Temporal Arteritides, Juvenile; Temporal Arteritis, Juvenile; Aortic Arteritis, Giant Cell; Aortitis, Giant Cell; Horton Giant Cell Arteritis; Temporal Arteritis

Nervous System Diseases: 14178
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Cerebrovascular Disorders: 7559
      - Central Nervous System Vasculitis: 369
        Giant Cell Arteritis: 1917
- Autoimmune Diseases of the Nervous System: 1461
  - Central Nervous System Vasculitis: 369
    - Giant Cell Arteritis: 1917
Cardiovascular Diseases: 91362
- Vascular Diseases: 15138
  - Vasculitis: 11851
    - Arteritis: 1407
      - Giant Cell Arteritis: 1917
    - Central Nervous System Vasculitis: 369
      - Giant Cell Arteritis: 1917
  - Cerebrovascular Disorders: 7559
    - Central Nervous System Vasculitis: 369
      - Giant Cell Arteritis: 1917
Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Vascular Skin Diseases: 528
    - Giant Cell Arteritis: 1917
Immune System Diseases: 4321
- Autoimmune Diseases: 34618
  - Autoimmune Diseases of the Nervous System: 1461
    - Central Nervous System Vasculitis: 369
      - Giant Cell Arteritis: 1917

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Drug/Important Bio-Agent (IBA)